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KMID : 1161420190220080823
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Journal of Medicinal Food
2019 Volume.22 No. 8 p.823 ~ p.832
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The Extract of Cordyceps Militaris Inhibited the Proliferation of Cisplatin-Resistant A549 Lung Cancer Cells by Downregulation of H-Ras
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Jeong Mi-Kyung
Yoo Hwa-Seung
Kang In-Cheol
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Abstract
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We investigated the antitumor effect of Cordyceps militaris extract (CME) on A549 cisplatin-resistant (CR) lung cancer cells. The proliferation of A549/CR cells was suppressed by CME. Apoptosis of the cells was induced by CME. The cell cycle arrest was observed in the sub-G1 phase in the cells treated with CME. Proteomic profile analysis showed that H-Ras was downregulated in CME-treated cells and it was confirmed by western blot analysis. Collectively, these data demonstrated that CME is an alternative treatment for the anticancer effect.
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KEYWORD
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A549 cisplatin resistance lung cancer cells, alternative treatment, anticancer effect, apoptosis, cell viability, Cordyceps militaris extract
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